Cachexia, a Systemic Disease beyond Muscle Atrophy
نویسندگان
چکیده
منابع مشابه
Running head: Stress and muscle cachexia Stress and Muscle Cachexia
One of the metabolic hallmarks of sepsis and severe injury is muscle cachexia, mainly reflecting increased protein breakdown, in particular myofibrillar protein breakdown. This review describes recent knowledge regarding the molecular mechanisms of sepsis-induced muscle cachexia. Among different intracellular proteolytic pathways, the energy-ubiquitindependent pathway is particularly important ...
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Skeletal muscle atrophy in cancer cachexia is mediated by the interaction between muscle stem cells and various tumor factors. Although Notch signaling has been known as a key regulator of both cancer development and muscle stem cell activity, the potential involvement of Notch signaling in cancer cachexia and concomitant muscle atrophy has yet to be elucidated. The murine K7M2 osteosarcoma cel...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21228592